2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Aldose Reductase

Aldose Reductase

Aldose Reductase

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Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.

Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-115977
    Aldose reductase-IN-3
    		Inhibitor
    Aldose reductase-IN-3 (Compound 5) is a potent and moderately selective inhibitor of aldose reductase (AR) with an IC50 of 3.99 μM. Aldose reductase has recently emerged as a molecular target that is involved in various inflammatory diseases, including sepsis. Aldose reductase-IN-3 has the potential for the research of sepsis.
    Aldose reductase-IN-3
  • HY-N6883
    6-Methoxytricin
    		Inhibitor
    6-Methoxytricin (Compound 6) is an flavonoid isolated from Artemisia iwayomogi. 6-Methoxytricin (Compound 6) is an inhibitor on aldose reductase (AR) and advanced glycation endproduct (AGE) formation activities with IC50 values of 30.29 μM and 134.88 μM, respectively. 6-Methoxytricin (Compound 6) has potential as an anti-diabetic complications agent.
    6-Methoxytricin
  • HY-N2494
    Hydroxyevodiamine
    		Inhibitor
    Hydroxyevodiamine inhibits aldose reductase with an IC50 value of 24.1 μM.
    Hydroxyevodiamine
  • HY-100969
    EBPC
    		Inhibitor
    EBPC is a potent and selective aldose reductase inhibitor with an IC50 of 47 nM.
    EBPC
  • HY-163609
    PROTAC AKR1C3 degrader-1
    		Degrader
    PROTAC AKR1C3 degrader-1 (compound 5) is a potent AKR1C3 PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)).
    PROTAC AKR1C3 degrader-1
  • HY-D0064
    6,7-Dihydroxy-4-coumarinylacetic acid
    		Inhibitor
    6,7-Dihydroxy-4-coumarinylacetic acid is a potent and selective inhibitor of ALR2. 6,7-Dihydroxy-4-coumarinylacetic acid inhibits ALR2, SDH andALR1 with IC50s of 9.6, 288 and 66.3 μM, respectively. 6,7-Dihydroxy-4-coumarinylacetic acid clearly suppresses galactitol accumulation.
    6,7-Dihydroxy-4-coumarinylacetic acid
  • HY-105485
    FR-62765
    		Inhibitor
    FR-62765 is a derivative of WF-3681. FR-62765 can significantly inhibit the accumulation of sorbitol in the sciatic nerve and the decrease of motor nerve conduction velocity in the tail of diabetic neuropathy rats, which can be used in the research of diabetic neuropathy.
    FR-62765
  • HY-144749
    AKR1C3-IN-5
    		Inhibitor
    AKR1C3-IN-5 (Compound 6e) is a potent inhibitor of AKR1C3. AKR1C3 enzyme is overexpressed in hormone-dependent prostate and breast tumors. AKR1C3-IN-5 derived from drupanin, which exhibits half-maximal inhibitory concentration (IC50) of 9.6 ± 3 μM and selectivity index (SI) of 5.5 against MCF-7 cells.
    AKR1C3-IN-5
  • HY-150648
    S07-2008
    		Inhibitor
    S07-2008 is a selective aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC50 of 0.16 μM. S07-2008 shows anticancer activities.
    S07-2008
  • HY-147875
    Aldose reductase-IN-6
    		Inhibitor
    Aldose reductase-IN-6 (Compound 3) is a competitive aldose reductase (AR) inhibitor with an IC50 of 3.164 μM and a Ki of 0.018 μM. Aldose reductase-IN-6 exhibits no cytotoxicity against healthy cells.
    Aldose reductase-IN-6
  • HY-173132
    AKR1Cs-IN-1
    		Inhibitor
    AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC50 values of 0.09, 0.28, 0.05, and 0.51 µM against AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer.
    AKR1Cs-IN-1
  • HY-173453
    AKR1C3-IN-15
    		Inhibitor
    AKR1C3-IN-15 (compound 30) is a potent and selective AKR1C3 inhibitor with an IC50 of 5 nM. AKR1C3-IN-15 enhances Sorafenib (HY-10201)-induced ROS generation, promoted apoptosis, and restored sorafenib sensitivity in HCC models both in vitro and in vivo.
    AKR1C3-IN-15
  • HY-157810
    AKR1C3-IN-11
    		Inhibitor
    AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC50 of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer.
    AKR1C3-IN-11
  • HY-N0033R
    Poliumoside (Standard)
    		Inhibitor
    Poliumoside (Standard) is the analytical standard of Poliumoside. This product is intended for research and analytical applications. Poliumoside, a caffeoylated phenylpropanoid glycoside, is isolated from Brandisia hancei stems and leaves. Poliumoside is an advanced glycation end product (AGE) formation and rat lens aldose reductase (RLAR) inhibitor, with IC50s of 19.69 and 8.47 μM, respectively. Poliumoside also has antiinflammatory and antioxidant activity.
    Poliumoside (Standard)
  • HY-N14447
    Salfredin A3
    		Inhibitor
    Salfredin A3 is an aldose reductase inhibitor.
    Salfredin A3
  • HY-N14186
    Asperaldin
    		Inhibitor
    Asperaldin is a potent aldose reductase (RLAR) inhibitor found in Aspergillus niger CFR-1046.
    Asperaldin
  • HY-N14431
    Salfredin C2
    		Inhibitor
    Salfredin C2 is an aldose reductase inhibitor.
    Salfredin C2
  • HY-N14451
    Salfredin C1
    		Inhibitor
    Salfredin C1 is an aldose reductase inhibitor.
    Salfredin C1
  • HY-50289R
    Sorbinil (Standard)
    		Inhibitor
    Sorbinil (Standard) is the analytical standard of Sorbinil. This product is intended for research and analytical applications. Sorbinil is an aldose reductase inhibitor (ARI) that prevents the accumulation of sorbitol in cells or animals. Sorbinil is useful in studying diabetes and diabetic complications, reducing AR activity and inhibiting the polyol pathway.
    Sorbinil (Standard)
  • HY-N4089R
    Quercetin 3-gentiobioside (Standard)
    		Inhibitor
    Quercetin 3-gentiobioside (Standard) is the analytical standard of Quercetin 3-gentiobioside. This product is intended for research and analytical applications. Quercetin 3-gentiobioside is isolated from A. iwayomogi, AR and AGE formation inhibitor, demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs).
    Quercetin 3-gentiobioside (Standard)
Cat. No. Product Name / Synonyms Application Reactivity